英文名：Ginsenoside Ro

中文名：人參皂苷Ro

CAS號：34367-04-9

分子式：C₄₈H₇₆O₁₉

分子量：957.12g/mol

結構類(lèi)型：Triterpenoids

來(lái)源：人參(Panax ginseng C. A. Mey.)

溶解性：溶于甲醇、水、DMSO，不溶于乙腈

LogP：2.7

藥理活性作用
一、抗炎及抗氧化作用
1.糖尿病視網(wǎng)膜病變(DR)

人參皂苷Ro通過(guò)調節AGEs損傷內皮細胞中的線(xiàn)粒體氧化應激和自噬來(lái)保護內皮細胞。此外，還通過(guò)改善糖尿病小鼠視網(wǎng)膜厚度、減少血管增生及抗炎抗氧化作用改善DR進(jìn)展。從作用機制而言，人參皂苷Ro促進(jìn)Epac1介導的AMPK信號通路激活。^[1]
2.腦缺血再灌注損傷

人參皂苷Ro具有顯著(zhù)的抗氧化活性，通過(guò)激活Nrf2/HO-1信號通路，減少OGD/R誘導的SH-SY5Y細胞氧化應激和凋亡，表現出潛在的藥用價(jià)值，可能成為治療腦缺血再灌注損傷的一種前景藥物。^[2]
3.骨關(guān)節炎(OA)

人參皂苷Ro通過(guò)抑制NF-κB信號通路，顯著(zhù)抑制了IL-1β誘導的大鼠軟骨細胞的凋亡和炎癥，具有作為OA治療的潛在天然藥物的潛力。^[3]
4.其他抗炎作用

在脂多糖(LPS)誘導的C57BL/6小鼠和RAW264.7巨噬細胞炎癥模型中，人參皂苷Ro通過(guò)直接抑制TLR4信號通路發(fā)揮抗炎作用。^[4]
二、神經(jīng)保護作用
1.阿爾茲海默癥

人參皂苷Ro通過(guò)減少Aβ沉積、改善神經(jīng)元凋亡和神經(jīng)炎癥，以及調控MAPK通路來(lái)實(shí)現改善空間探索能力、記憶認知功能。具有開(kāi)發(fā)成為AD治療藥物的潛力。^[5][6]

三、血管保護作用
人參皂苷Ro通過(guò)抑制PI3K/Akt信號通路，顯著(zhù)抑制了血小板聚集、纖維蛋白原和纖連蛋白的結合以及血塊回縮。這些發(fā)現表明人參皂苷Ro可能具有預防血栓形成和其他血小板介導的心血管疾病的潛力。^[8]
此外，G-Ro通過(guò)減弱cPLA2的磷酸化和減少AA的釋放來(lái)抑制TXA2的生成，從而對抗血栓素相關(guān)的血栓形成。這些發(fā)現為G-Ro作為抗血小板藥物的潛在應用提供了理論依據。^[9]
四、抗癌作用
研究者通過(guò)酶轉化將人參皂苷Ro轉化為人參葡萄糖基齊墩果酸(GGO)，通過(guò)抑制PI3K/AKT/HIF-1α信號通路，減少HIF-1α的核轉位和VEGF的表達，從而抑制宮頸癌細胞的增殖和血管生成。^[10]

五、抗微生物作用

人參皂苷Ro通過(guò)抑制SopB和SopE2的活性，阻斷RAC1/CDC42/ARP2/3信號通路，減少沙門(mén)氏菌(S.Typhimurium)的入侵和復制，從而改善小鼠的結腸炎癥狀。^[11]

普思生物可大量供應人參皂苷Ro，我司可提供百克級現貨及公斤級定制。

理化數據來(lái)源：普思生物官網(wǎng)、PubChem、HMDB
參考文獻：
[1] Liu J, Zhang Y, Xu X, Dong X, Pan Y, Sun X, Luo Y. Ginsenoside Ro prevents endothelial injury via promoting Epac1/AMPK- mediated mitochondria protection in early diabetic retinopathy. Pharmacol Res. 2025 Jan;211:107562.
[2] 張苗苗,胡利明,周全,等.人參皂苷Ro對氧糖剝奪/復糖復氧誘導SH-SY5Y細胞損傷的保護作用及機制[J].中國神經(jīng)免疫學(xué)和神經(jīng)病學(xué)雜志,2025,32(01):35-41.
[3] Zhang XH, Xu XX, Xu T. Ginsenoside Ro suppresses interleukin-1β-induced apoptosis and inflammation in rat chondrocytes by inhibiting NF-κB. Chin J Nat Med. 2015 Apr;13(4):283-9.
[4] Xu HL, Chen GH, Wu YT, Xie LP, Tan ZB, Liu B, Fan HJ, Chen HM, Huang GQ, Liu M, Zhou YC. Ginsenoside Ro, an oleanolic saponin of Panax ginseng, exerts anti-inflammatory effect by direct inhibiting toll like receptor 4 signaling pathway. J Ginseng Res. 2022 Jan;46(1):156-166.
[5] Li T, Chen J, Xie Z, Fang J, Wu Q, Cao X, Chen Z, Wang Y, Fan Q, Wang Q, Liu J. Ginsenoside Ro ameliorates cognitive impairment and neuroinflammation in APP/PS1 mice via the IBA1/GFAP-MAPK signaling pathway. Front Pharmacol. 2025 Feb 24;16:1528590.
[6] Li Y, Wang T, Li H, Jiang Y, Shen X, Kang N, Guo Z, Zhang R, Lu X, Kang T, Li M, Hou Y, Wu Y. Targeting LKB1-AMPK-SIRT1-induced autophagy and mitophagy pathways improves cerebrovascular homeostasis in APP/PS1 mice. Free Radic Biol Med. 2025 Apr 1:S0891-5849(25)00195-9.
[7] Ren JL, Zhang XL, Zhao LJ, Wen GY, Liu JF, Meng QY, Yang Z, Song LL, Zhang YJ. Unveiling the neuroprotective mystery of Kaixinsan: identifying and validating the neuroprotective ingredients under the perspective of gut - brain axis regulation. J Asian Nat Prod Res. 2025 Mar 3:1-18.
[8] Kwon HW. Inhibitory Effects of Ginsenoside Ro on Clot Retraction through Suppressing PI3K/Akt Signaling Pathway in Human Platelets. Prev Nutr Food Sci. 2019 Mar;24(1):56-63.
[9] Shin JH, Kwon HW, Rhee MH, Park HJ. Inhibitory effects of thromboxane A2 generation by ginsenoside Ro due to attenuation of cytosolic phospholipase A2 phosphorylation and arachidonic acid release. J Ginseng Res. 2019 Apr;43(2):236-241.
[10] Liu S, Ai Z, Hu Y, Ren G, Zhang J, Tang P, Zou H, Li X, Wang Y, Nan B, Wang Y. Ginseng glucosyl oleanolate inhibit cervical cancer cell proliferation and angiogenesis via PI3K/AKT/HIF-1α pathway. NPJ Sci Food. 2024 Dec 19;8(1):105.
[11] Cui X, Wang Y, Liu Z, Zhao M, Zhu M, Yu W, Lu B, Xu H, Liu J, Liao N, Shi J, Peng D, Niu S, Shen J, Qiu J, Yu L. Ginsenoside Ro improves Salmonella Typhimurium-induced colitis through inhibition of the virulence factors SopB and SopE2 via the RAC1/CDC42/ARP2/3 pathway. FASEB J. 2024 Dec 13;38(24):e70282.
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